Our laboratory studies the role of fluid mechanical stresses (e.g., fluid shear stresses, normal stresses or pressures) in regulating human physiology and pathobiology at the cellular level. We direct our efforts in identifying and characterizing the cellular component(s) responsible for sensing and converting imposed mechanical stresses into a biological event, i.e. mechanotransduction. Moreover, we study how changes in the ability of these cell to sense mechanical stresses due to disease states impacts downstream cell functions and contributes to disease.
The broad objectives of our research efforts are to:
(1) define the role of mechanics in the biology of the cell as part of a basic research initiative to investigate mechanobiology in physiology and disease;
(2) promote interest in educational pursuits related to biomedical engineering, biomechanics, and cell mechanobiology;
(3) advocate an understanding of biology in the context of the mechanoenvironment of all living organisms (i.e., from cells to tissues to animals);
(4) increase awareness of cell mechanosensitivity among the general population; and
(5) adopt an application-oriented research program that utilizes our results to develop tools and tissue engineering approaches that will lead to new strategies for studying cellular mechanobiology as well as for diagnosing and treating related diseases.
Finally, we offer services to provide experimental support or material as it relates to assessing or screening the involvement of mechanobiology in the biological/physiological activity of interest to you. Please don’t hesitate to contact us if you are interested in seeking our assistance.